A city-center car is rarely necessary for sightseeing, but renting one becomes useful for the Taunus, Rhine Valley, small towns, business sites, or a multi-day road trip. The best branch depends on when the car is actually needed. Picking up at Hauptbahnhof avoids an airport trip, while airport branches usually offer broader hours and more vehicles. Neighborhood branches can be easier when the hotel sits away from both transport hubs.
Rental quotes should be compared on the full terms, not the base price. Insurance excess, fuel policy, deposit, mileage, additional drivers, border crossings, and one-way returns can change the real cost substantially. Automatic transmissions and larger vehicles are worth reserving early. Before leaving, photograph existing damage and understand the parking and low-emission rules at the first destination.
Frankfurt has major international rental companies at Hauptbahnhof, the airport, the center, Sachsenhausen, and Ostend. The list below focuses on currently active branches with different pickup advantages, allowing travelers to choose based on route rather than brand name alone.
SIXT Frankfurt Hauptbahnhof
SIXT Frankfurt Hauptbahnhof places a major rental desk directly at the central station, convenient for collecting a car only when the rail-based part of the trip is finished. It is especially useful for city-center stays, onward road trips, and travelers arriving by train. Confirm where the vehicle itself is parked and how after-hours return works, because station pickup and garage access may involve different areas.
Address: Im Hauptbahnhof / Mietwagenzentrum, 60329 Frankfurt am Main, Germany / Visit Map
Europcar Frankfurt Hauptbahnhof
Europcar Frankfurt Hauptbahnhof offers another full-service rental option inside the main station, making brand and vehicle comparisons possible without traveling to the airport. It is especially useful for rail arrivals, one-way rentals, and travelers wanting a central pickup.
Check the reserved vehicle class and return instructions in advance, especially if the route ends outside Frankfurt or at the airport.
Address: Im Hauptbahnhof 1, 60329 Frankfurt am Main, Germany / Visit Map
Hertz Frankfurt Hauptbahnhof
Hertz Frankfurt Hauptbahnhof provides a station-area branch for travelers who prefer to switch from train to car in the center rather than adding an airport transfer. It is especially useful for business trips, central hotel departures, and familiar Hertz loyalty users. Opening hours can be narrower than airport locations, so match pickup and return times carefully to avoid forcing an unnecessary schedule change.
Address: Am Hauptbahnhof, 60329 Frankfurt am Main, Germany / Visit Map
Enterprise Frankfurt Zentrum Zeil
Enterprise Frankfurt Zentrum Zeil adds a rental branch east of the main shopping district, useful for guests based around Zeil, Ostend, or the old town who want to avoid Hauptbahnhof. It is especially useful for central residents and visitors starting a road trip from the eastern center. Check garage directions before pickup, because driving away from a dense central street is easier when the first route is already planned.
Address: Lange Str. 65, 60313 Frankfurt am Main, Germany / Visit Map
Enterprise Frankfurt Hauptbahnhof
Enterprise Frankfurt Hauptbahnhof operates near the south side of the main station, giving travelers another central option with different opening and fleet patterns. It is especially useful for station-area hotels, families, and travelers comparing Enterprise with in-station desks.
Verify the exact pickup desk and vehicle location, as the address is outside the main terminal building rather than on a rail platform level.
Address: Mannheimer Str. 21, 60329 Frankfurt am Main, Germany / Visit Map
Avis Frankfurt Sachsenhausen
Avis Frankfurt Sachsenhausen provides a south-bank branch that can be more convenient than the station for travelers staying around Sachsenhausen. It is especially useful for south-side hotels, local road trips, and renters avoiding the busiest station district. Check weekend hours carefully and plan the first driving route before leaving, because nearby streets can be busy and one-way patterns are easy to miss.
Address: Schulstraße 7, 60594 Frankfurt am Main, Germany / Visit Map
Europcar Frankfurt Ostend
Europcar Frankfurt Ostend offers a larger east-side location on Hanauer Landstraße with broad access hours, useful for travelers leaving the city toward eastern routes. It is especially useful for Ostend stays, business users, and renters who value vehicle access over a walkable tourist location. The road-oriented setting suits drivers, but confirm public-transport access for the pickup if the group is arriving without a car.
Address: Hanauer Landstraße 334, 60314 Frankfurt am Main, Germany / Visit Map
Avis Frankfurt Airport
Avis Frankfurt Airport provides airport rental access with long daily hours and a large international-traveler focus, useful when driving starts immediately after landing. It is especially useful for airport arrivals, multi-day road trips, and late or early pickups.
Follow the terminal rental-car signs and allow time for paperwork and garage collection rather than booking a tight first appointment after landing.
Address: Hugo-Eckener-Ring 1, 60549 Frankfurt am Main, Germany / Visit Map
Enterprise Frankfurt Airport
Enterprise Frankfurt Airport offers airport pickup with long operating hours and a broad fleet, useful when a city-center detour would add unnecessary time. It is especially useful for families, business trips, and travelers continuing directly by road from the airport. Confirm terminal and return instructions in the reservation because airport road layouts are large and rental-car return can take longer than expected.
Address: Mietwagenzentrum, Flughafen Terminal 1-3, 60549 Frankfurt am Main, Germany / Visit Map
Budget Frankfurt Airport
Budget Frankfurt Airport adds another major rental counter for travelers who want to collect a car immediately after landing rather than navigate into the center first. It is most useful for onward trips to the Rhine, Taunus, business parks, or destinations poorly served by rail. Airport pricing and vehicle categories can vary sharply by date, so compare the total rate, insurance terms, deposit, fuel policy, and exact terminal collection instructions before booking.
Address: Hugo-Eckener-Ring 1, 60549 Frankfurt am Main, Germany / Visit Map